To study plants purification capability of Cu and Pb on two cultivars of vetch plant (Vigna Radiata) in contaminated soils and their effects on morphological characteristics, we conducted a completely randomized trial as factorial. Different concentrations of Cu (0, 150, 300, and 400 mg/ Kg of dried soil) and Pb (0,200,400, and 600 mg/ kg of soil) were used.\n After four weeks growth on contaminated soil, parameters such as aerial parts height, roots, fresh and dry weight, as well as intake and aggregation levels of Cu and Pb in aerial parts and roots were measured in both cultivars of Sistan and Gohar.\nAnalysis results indicated that increased levels of Cu and Pb lead to decreased height of aerial parts and roots, and dry and fresh weight of both cultivars. Measuring of metal content showed that with increase in metals concentration in soils, their aggregation into aerial parts will be increased. By applying Cu and Pb at the same time, Cu intake will be increased, so a higher level of Pb leads to increased intake of Cu, but Pb intake was decreased in the presence of Cu. Metal aggregation within aerial parts and roots was not different significantly, indicating metals transferring from roots to aerial parts. Results show that the vetch plant is able to purify soils and intake heavy metals such as Cu and Pb from it.
One of the leading causes for death after heart diseases and cancer in all over the world is still stroke. Most of the time, as with heart attacks, the problem is atherosclerosis, hardening of the arteries, calcified buildup of fatty deposits on the vessel wall. The primary troublemaker is the carotid artery, one on each side of the neck, the main thoroughfare for blood to the brain. Only within the last twenty-five years, though, have researchers been able to put their finger on why the carotid is especially susceptible to atherosclerosis. In this study, the fluid dynamic simulations were done in a diseased carotid bifurcation under the steady flow conditions computationally. Reynolds numbers representing the steady flow were above 2300 for diastolic, average and systolic peak flow represented by pulsatile flow waveform in abnormal condition, respectively. The boundary conditions and the geometry were obtained from the literature. The pressure and velocity contours were obtained in different stenosis percentage including 50,70 and 80. The results were compared with the clinical relevance and the literature.
Acute Mylenoid Leukemia is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation of blood cells, usually white blood cells. A number of genes are involved in regulating heamatopoiesis, and thereby affecting the susceptibility to Leukemia. Among them is the gene which is responsible for FMS like-tyrosine kinase-3 (FLT3). FLT3 is important protein that plays a role in cell proliferation and differentiation. In this work A 3D model of FLT3 was generated using 1RJB (Chain A: Crystal structure of Juxtamembrane domain of FLT3) as template with the help of Modeller7v7. With the aid of the molecular mechanics and molecular dynamics methods, the final model is obtained and is further assessed by Procheck and Verify 3D graph programs, which showed that the final refined model is reliable. After energy minimization we compared the 3D structure of FLT3 with template. We identified 21 genes coding for FLT3 and their locus regions. Multiple alignment and phylogenetic analysis showed that the total FLT3 family proteins formed 4 branches. From the result we identified mutations within FLT3 domain region.
Biological tissues containing the tropolone structure characterized by a seven-membered ring and an alpha-hydroxyl ketone, called tropolonoids or troponoids, are distributed in some plants, bacteria and fungi, although they are relatively rare. ß-Thujaplicin (2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), also known as hinokitiol, is a natural compound found in several plants of the Cupressaceae family. Besides hinokitiol, related compounds were identified in Cupressaceae trees. It has been demonstrated that hinokitiol and its derivatives have various biological effects, such as antibacterial, antifungal, insecticodal, antimalarial, antitumor, anti-ischemic, iron chelating and the inhibitory activity against polyphenol oxidase activity. Activity similar to ß-thujaplicin has tropolone and its derivatives, which are not present in nature. Due to the high scientific and practical interest, synthetic ß-thujaplicin and other troponoids have been produced for many years. In this review, the major biological effects of troponoids, mostly ß-thujaplicin and tropolone, on tyrosinase and polyphenol oxidase activity, ethylene production, antibacterial, antifungal and insecticidal activities, and biotransformation of ß-thujaplicin by cultured plant cells are presented. Accumulation of ß-thujaplicin and related troponoids has been shown in cell cultures of Cupressus lusitanica and other species of Cupressaceae. The biosynthetic pathway of the troponoids in plants, bacteria and fungi has been also briefly described