Title: Ordered nearness semigroups

Abstract:In mathematics, a semigroup is an algebraic structure consisting of a set together with an associative binary operation. The first to use the term \"semigroup\" in the modern sense was Harold Hilton in his book on finite groups in 1908 [6]. The semigroups have a lot of generalizations. One of them is the neaerness semigroup. Near set theory which is a generalization of rough set theory is based on the determination of universal sets according to the available information of the objects. İnan and Öztürk applied the notion of near sets defined by J. F. Peters to the semigroups [10]. \nIn this paper, our aim is to define ordered semigroups on weak near approximation spaces. Moreover, we explored some properties of these ordered nearness semigroups.




Title: An Intelligent Melanoma Skin Cancer Classification Approach

Abstract:This paper aims to analyse the performance of machine learning algorithms in detecting skin cancer types. Skin cancer has various types, some of which may lead to death. Therefore, early detection of skin cancer can help reduce the death rate. Our dataset was extracted from the archive of The International Skin Cancer Collaboration of imaging (ISIC). The dataset consists of 2637 benign and malignant images for training and 660 benign and malignant images for testing. The goal of this paper is to identify the algorithm that gives the maximum accuracy in detecting skin cancer types when applied on dataset images. The algorithms applied are Convolution Neural Network (CNN), Support Vector Machine (SVM) and Artificial Neural Network (ANN). The obtained results showed that Convolution Neural Network algorithm provided the highest accuracy (0.90) comparing to the Artificial Neural Network (0.84) and Support Vector Machine (0.83) algorithms.




Title: TinyML: Enabling of inference Deep learning models on Ultra-Low-Power IoT Edge Devices for AI Applications

Abstract:With the proliferation of machine learning applications in all the surrounding fields and the rapid spreading of the internet of things (IoT), there is a growing need to merge between both of them. For this reason, there had to be an intersection between machine learning (ML) and the tiny edge in the internet of things (IoT) called Tiny machine learning (TinyML). TinyML is a recent technology that can be used to improve edge devices with low power consumption to engage machine learning (ML)and deep learning (DL) as well. This technology can change the way of communication between IoT devices and their data by allowing the device to interact with the data locally without sending it to the cloud. In this paper, we present an overview of the revolution of TinyML and its benefits. As well, we provide holistic coverage of TinyML studies that present the studies based on the DL methodologies, models, metrics and studies concerning the devices design considerations. Moreover, the used datasets in TinyML applications are demonstrated and the different devices are also explained.




Title: Is Septoplasty under local anesthesia safe for every cases?

Abstract:Introduction:\nSeptoplasty is a common day-case surgery, can be performed both under local or general anesthesia in otorhinolaryngology practice. It is not a consensus that local septoplasty is a difference in terms of complications and surgical comfort compared to general anesthesia. Our aim is to compare both methods in intraoperative and postoperative periods.\nMaterial and method:\nIn total, two groups of 437 patients were all male patients. The patients were between 19-53 years of age. Group 1 consisted of 397 patients and Group 2 consisted of 40 patients. Surgical duration, intraoperative and postoperative bleeding amount, pain by Visual Analog scale (VAS) scores were compared.\nResults:\nLess intraoperative bleeding, postoperative bleeding and nausea were observed under local anesthesia (p <0.05). Severe arrhythmia was observed in 1 patient in the case of local surgery, and 1 patient with septoplasty under general anesthesia had severe intraoperative bleeding.\nConclusion:\nThere was no difference between the groups in terms of septoplasty satisfaction. Less intra- operative and postoperative bleeding are the advantages of local septoplasty. In experienced hands, local surgery is a method that can be preferred for both physician and patient.




Title: Picture Fuzzy Proximity Relations via Relator Spaces

Abstract:Picture fuzzy sets are an advanced tool of three-dimensional membership functions which consist of membership, non-membership and hesitancy degrees. In this paper, it is introduced a new approach via proximal spaces for picture fuzzy sets. To do this, the picture fuzzy proximity axioms are defined on proximal relator spaces and given some examples related to the subject.




Title: Species isolation, identification and in vitro antifungal susceptibility testing of moulds and yeasts isolated from Otomycosis patients in Duhok city/Iraq

Abstract:The aim of this study was to establish the most common causative agents of otomycosis in Duhok city, and study their sensitivity to the antifungal medications that are commonly prescribed. From June to august 2021, a total of 90 patients (46 females and 44 males) were clinically examined for mycotic otitis who attended the outpatient clinic of ear, nose and throat (ENT) department at Azadi teaching hospital. Ear debris collected by sterile swabs and transferred to the laboratory for direct microscopic and macroscopic examination by culturing on sabouraud dextrose agar, potato dextrose agar and CHROM Agar. Antifungal drugs were dissolved with (dimethyl sulfoxide) DMSO and used for evaluation of antifungal sensitivity by agar well diffusion method against commonly used antifungal drugs namely; Fluconazole, Itraconazole, Terbinafine, Nysatin, Amphotericin B, and Clotrimazole. In this study positive fungal infection were found in 88 (97.8%) of the collected samples, and it was more common among patients that aged 40 to 49 years old. Mycological examination revealed the isolation of 24 species belong to 6 genera with one variety. The most common fungal isolates were Candida (88.9%), followed by Aspergillus (28.8%) and non-identified yeast (25%), then Penicillium (8.9%). Candida krusei (44.4%) and candida albicans (16.7%) followed by Aspergillus niger (15.6%) were the predominant species isolates. In vitro antifungal susceptibility pattern analysis revealed that yeast had the highest sensitivity to (itraconazole) followed by (amphotericin B). while moulds isolates, their highest sensitivity was to (clotrimazole) followed by (terbinafine).




Title: UAV Robust Flight Control System Design Utilizing Optimal Dynamic Programming

Abstract:The design complexities of trending UAVs necessitates Control Law formulation utiliz-ing intelligent techniques that are robust and modal-free. In this research, a controlarchitecture to maximize UAV glide range for an experimental UAV is presented. Tohandle control complexities, while keeping them computationally acceptable, a distinctRL technique namely Modied Model Free Dynamic Programming (MMDP) is proposed.The methodology has been specically modied to congure the problem in continuousstate and control space domains. The ecacy of the results and performance charac-teristics, demonstrated the ability of the presented algorithm to dynamically adapt tothe changing environment, thereby making it suitable for UAV applications. Nonlinearsimulations performed under dierent environmental conditions demonstrated the eec-tiveness of the proposed methodology over the conventional classical approaches.




Title: Omarigliptin has anti-apoptotic and beneficial metabolic effects in acute neuropathic-type Gaucher disease cells

Abstract:Gaucher disease (GD) is one of the most common lysosomal storage disorders and is caused by an inherited deficiency in glucocerebrosidase. Dipeptidyl peptidase-4 inhibitors have demonstrated multiple beneficial activities, including anti-diabetic, anti-oxidant, anti-apoptotic, and neuroprotective effects. The aim of this study was to determine if omarigliptin, a dipeptidyl peptidase-4 inhibitor, has a therapeutic effect on fibroblast cells derived from patients with type II GD. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays were performed to determine the effect of omarigliptin on cell viability. The expression patterns of apoptosis-inducing factor (AIF), Bcl-2-associated X protein (Bax), caspase-3, acetyl-coenzyme A acetyltransferase 1 (ACAT1), E3-binding protein (E3BP), and citrate synthase (CS) were evaluated by western blotting to characterize the effect of omarigliptin treatment on GD cells. Thin-layer chromatography (TLC) was performed to determine glucosylceramide levels in omarigliptin-treated GD cells. Omarigliptin increased GD cell viability compared to untreated control cells. Further, omarigliptin treatment dose-dependently decreased the apoptotic factors AIF, Bax, and cleaved caspase-3 levels, whereas ACAT1, E3BP, and CS expression dose-dependently increased. TLC analysis showed reduced levels of intracellular glucosylceramides in omarigliptin-treated GD cells. These findings demonstrate that omarigliptin can reduce cellular stress resulting from glucosylceramide accumulation, and suggest that omarigliptin should be studied further as a novel therapeutic agent for GD.




Title: Preclinical evidence for the role of the resveratrol derivative HG-101 in the treatment of neuronopathic Gaucher disease

Abstract:Gaucher disease is the most common lysosomal storage disorder. Resveratrol is a phytoalexin that possesses a wide range of beneficial effects, including anti-inflammatory, anti-oxidant, and neuroprotective properties. This study was conducted to determine whether the resveratrol derivative HG-101 has a therapeutic effect on primary fibroblast cells derived from patients with type III Gaucher disease. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays were performed to determine the effect of HG-101 on cell survival. The expression levels of apoptosis-inducing factor (AIF), Bcl-2-associated X protein (Bax), caspase-3, acetyl-coenzyme A acetyltransferase 1 (ACAT1), E3-binding protein (E3BP), and citrate synthase (CS) were evaluated by western blotting to characterize the effect of HG-101 treatment on Gaucher disease cells. Thin-layer chromatography (TLC) was carried out to measure changes in glucosylceramide levels in HG-101-treated patient cells. HG-101 increased the viability of patient cells compared to that of untreated control cells. HG-101 treatment dose-dependently decreased AIF, Bax, and cleaved caspase-3 levels, whereas ACAT1, E3BP, and CS expression dose-dependently increased. TLC analysis showed reduced levels of glucosylceramides in HG-101-treated patient cells. These findings demonstrate that the resveratrol derivative HG-101 can relieve cellular stress due to glucosylceramide accumulation, and suggest that it should be studied further as a new therapeutic approach for the treatment of neuronopathic Gaucher disease.




Title: Therapeutic potential of dipeptidyl peptidase-4 inhibitors in type I Gaucher disease

Abstract:Gaucher disease (GD) is the most prevalent lysosomal storage disorder caused by an inherited deficiency of glucocerebrosidase. In the present study, we aimed to determine whether dipeptidyl peptidase-4 inhibitors (DPP4i) exhibit a potential therapeutic effect in type I GD cells. Four kinds of DPP4i were tested in dermal fibroblasts from patients with type I GD. MTT assays were performed to determine their effects on cell viability. The expression levels of Bcl-2-associated X protein (Bax), ATP-citrate synthase (ATP-CS), E3-binding protein (E3BP), and acetyl-coenzyme A acetyltransferase 1 (ACAT1) were determined by western blotting to understand the molecular mechanism of DPP4i in cells. Thin-layer chromatography (TLC) was carried out to measure changes in glucosylceramide levels in cultured fibroblasts. This investigation showed that DPP4i increased cell viability more than 1.45 times. After exposure to DPP4i, the expression level of Bax decreased, whereas those of ATP-CS, E3BP, and ACAT1 increased. TLC revealed reduced amounts of intracellular glucosylceramides in type I GD patient cells. Here, we suggest that DPP4i can reduce cellular stress by glucosylceramide accumulation, and that it may be utilized as a new therapeutic approach for Gaucher disease.